GABAergic modulation of developing pedunculopontine nucleus
نویسندگان
چکیده
منابع مشابه
GABAergic neuron distribution in the pedunculopontine nucleus defines functional subterritories.
gamma-Aminobutyric acid (GABA)ergic neurons are widely distributed in brainstem structures involved in the regulation of the sleep-wake cycle, locomotion, and attention. These brainstem structures include the pedunculopontine nucleus (PPN), which is traditionally characterized by its population of cholinergic neurons that have local and wide-ranging connections. The functional heterogeneity of ...
متن کاملTopographical Organization of the Pedunculopontine Nucleus
Neurons in the pedunculopontine nucleus (PPN) exhibit a wide heterogeneity in terms of their neurochemical nature, their discharge properties, and their connectivity. Such characteristics are reflected in their functional properties and the behaviors in which they are involved, ranging from motor to cognitive functions, and the regulation of brain states. A clue to understand this functional ve...
متن کاملMC4R expression in pedunculopontine nucleus involved in the modulation of midbrain dopamine system.
BACKGROUND AND OBJECTIVE Separate studies have implicated the pedunculopontine tegmental nucleus (PPTg) in processing aversive stimuli to dopamine systems, and melanocortin-4 receptor (MC4R) are broadly expressed by the neurons in the PPTg, but the exact neurosubstrate underlying the regulation of dopamine systems by the central melanocortin pathway is poorly understood. METHODS In this study...
متن کاملPedunculopontine nucleus: functional organization and clinical implications.
The pedunculopontine tegmental nucleus (PPN) is a neurochemically and functionally heterogeneous structure that occupies a strategic position in the dorsal tegmentum of the midbrain and upper pons. The PPN contains cholinergic, γ-aminobutyric acid (GABA)ergic, and glutamatergic neurons; it receives direct input from the cerebral cortex, is reciprocally connected with the basal ganglia, and prov...
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ژورنال
عنوان ژورنال: NeuroReport
سال: 2007
ISSN: 0959-4965
DOI: 10.1097/wnr.0b013e328011e6c9